A major concern for many industries across the world is the formation of biofilms within their production systems. Harmful biofilms cause the loss of billions of dollars due to reduced productivity, decreased product quality, and greater time and expense for biofilm removal. There is also the health of the public to consider in food industries. Prevention of biofilms has proven difficult and most companies can only manage biofilms once they appear. A large number of Bacillus species and certain Archaea secrete enzymes that can help degrade the structure of biofilms. Using nonpathogenic species of Bacteria and Archaea to clean and prevent biofilms could prove to be an effective method of control.